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KMID : 1149220140220020087
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Korean Journal of Oriental Medical Prescription
2014 Volume.22 No. 2 p.87 ~ p.103
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Anti-oxidative and Anti-inflammatory Effect of 7 Herbal Extracts and Methods of Herbal Formula Compositioning
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Park Jeong-Hoo
Park Ju-Yeon
Park Sun-Dong
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Abstract
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Objectives : Herbal formulas are complicated to analyze and difficult to compose because of its mixed, complex features. So we discussed about how to compose herbal formulas effective and efficient by analyzing various effectiveness of each herbal extracts.
Methods : To evaluate the effectiveness of herbal formula, anti-oxidative and anti-inflammatory effectiveness were mathematically analyzed. DPPH, superoxide anions, Nitric Oxide scavenging activity was measured to evaluate the effectiveness of 7 herbal extracts. And next, cytotoxic activity of extracts on RAW 264.7 cells were measured using MTS assay. To asses anti-inflammatory effect, nitric oxide and PGE2 production were measured. Based on these anti-oxidative and anti-inflammatory experiment result, mathematical analyzation were carried out with constOptm function, and determined efficacy-maximizing ratio.
Results : This mathematical analysis based formula showed significantly outstanding effectiveness than other formulae. And estimated tendency of anti-inflammatory effectiveness was matched with real effectiveness.
Conclusions : So, mathematical analysis can be available to evaluate and estimate the effectiveness of herbal formulae.
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KEYWORD
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Herbal formula, Mathematical analysis, Anti-inflammatory, Anti-oxidative stress
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